There are new and important advancements in todays complexity theories in ICT and requires an extraordinary perspective on the interaction between living systems and information technologies. With human evolution and its continuous link with the development of new tools and environmental changes, technological advancements are paving the way for new evolutionary steps. Complexity Science, Living Systems, and Reflexing Interfaces: New Models and Perspectives is a collection of research provided by academics and scholars aiming to introduce important advancements in areas such as artificial intelligence, evolutionary computation, neural networks, and much more. This scholarly piece will provide contributions that will define the line of development in complexity science.