In this issue of Urologic Clinics of North America, guest editors Drs. Benjamin T. Ristau and Alexander Kutikov bring their considerable expertise to the topic of Comprehensive Medical and Surgical Management of Adrenal Pathology. Top experts provide coverage of adrenal physiology and pathophysiology, with specific attention paid to challenging medical management issues such as how to handle adrenal incidentalomas in urologic practice, nuances of adrenal metabolic workup, technical challenges and techniques for adrenal venous sampling, and surgical techniques. In addition, the issue will feature a patient perspective on living with pheochromocyoma and opportunities for advocacy.