Concepts in Viral Pathogenesis III de Abner L. Notkins

Concepts in Viral Pathogenesis III

Abner L. Notkins

Michael B.A. Oldstone

The all new Concepts in Viral Pathogenesis III contains the widely praised format of presenting up-to-date information in pithy, easily read "mini-review" style and complements previous editions with contributions by leading international authorities on structure-function relationships, gene regulation, cell biology of viral infections, transgenic mice, expression of viral genes, retroviruses, and evolving concepts in viral diseases. Taken together, Volume I, II and III of Concepts in Viral Pathogenesis contain 145 unique chapters each representing the latest thinking in important areas of virology by the foremost investigators in the field. Clinicians, laboratory scientists, students, and others seeking authoritative overviews of current knowledge on the mechanism of viral diseases will welcome this valuable resource.

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Cuprins

Structure—Function Relationship.- 1. Common Features in the Design of Small RNA Viruses.- 2. Structural Determinants of Serotype Specificity and Host Range in Poliovirus.- 3. The Molecular and Functional Basis of Poliovirus Attenuation and Host Range.- Gene Regulation.- 4. Role of Enhancer Regions in Leukemia Induction by Nondefective Murine C Type Retroviruses.- 5. Molecular Aspects of Pathogenesis in the Polyoma Virus—Mouse System.- 6. Activation of Adenovirus Gene Expression.- 7. Cis- and Trans-Activation of HIV.- 8. Herpes Virus Vectors.- 9. Recombinant Proteins Expressed by Baculovirus Vectors.- 10. Transforming Genes of Bovine and Human Papillomaviruses.- Cell Biology of Viral Infections.- 11. Retrovirus Receptors and Cell Tropism.- 12. Coronavirus Receptors.- 13. Penetration of Influenza Virus Into Host Cells.- 14. Adenoviral Immune Suppression.- 15. Antigen Recognition by Cytotoxic T Cells.- 16. The Use of the Epstein—Barr Virus to Probe the Human B Cell Repertoire and to Generate Monoclonal Antibodies.- 17. Transcriptional Regulation by Papillomavirus E2 Gene Products.- Transgenic Mice: Expression of Viral Genes.- 18. Expression of SV40 Early Region Genes in Transgenic Mice.- 19. Analysis of Hepatitis B Virus Gene Expression in Transgenic Mice.- 20. Expression of HTLV-1 in Transgenic Mice.- 21. Targeted Expression of Viral Genes to Pancreatic ? Cells in Transgenic Mice.- Retroviruses.- 22. Evolution of Retroviruses.- 23. New HIV-Related Viruses.- 24. The HTLV-I Model and Chronic Demyelinating Neurologic Diseases.- 25. Mechanism of CD4+ Cell Killing by the Human Immunodeficiency Virus.- 26. Human and Simian Immunodeficiency Viruses in Nonhuman Primates.- 27. Mechanisms of Persistent Replication of Lentiviruses in Immunocompetent Hosts.- 28. Generation ofPathogenic Feline Leukemia Viruses.- 29. Neurovirulent Retrovirus of Wild Mice.- Evolving Concepts in Viral Diseases.- 30. Mechanisms of Hepatic Oncogenesis During Persistent Hepadna Virus Infection.- 31. Molecular Basis of Rhabdovirus Pathogenicity.- 32. Gene Functions Directing Adenovirus Pathogenesis.- 33. Enterovirus-Induced Cardiomyopathy.- 34. Hantavirus Infection: A Newly Recognized Viral Enzootic of Commensal and Wild Rodents in the United States.- 35. Virus-Induced Cell-Mediated Autoimmunity.- 36. Immunological Tolerance in Viral Infections.- Control of Viral Diseases.- 37. Designing Peptides to Immunologically Distinguish Specific Human Immunodeficiency Virus Isolates.- 38. Control of Hepatitis B by Vaccination.- 39. Antiviral Compounds Bind to a Specific Site Within Human Rhinovirus.- 40. HIV: Antiviral Chemotherapy.- 41. Treatment of Cytomegalovirus.- 42. The Mechanism of Action of Amantadine and Rimantadine Against Influenza Viruses.- 43. Control of Insect Pests by Baculoviruses.