The purpose of this Special Issue "Cow's Milk and Allergy" is to provide an overview of the association of cow's milk with allergy. This topic has two quite different faces. On the one hand, we are all aware of the importance of cow's milk allergy in early life. What is less known is that the consumption of raw, unprocessed milk is associated with a lower incidence of asthma and rhinitis. This Special Issue takes a closer look at all of these aspects of cow's milk and allergy and focus on the following questions: -Mechanisms of cow's milk allergy -Epidemiology of cow's milk allergy -Prevention of cow's milk allergy -Management and immunotherapy of cow's milk allergy -Milk processing, baked milk, and cow's milk allergy -The consumption of raw milk and inhalation allergies