The First Meeting on CPT and Lorentz Symmetry, held at Indiana University in November, 1998, focused on recent developments involving tests of the fundamental space-time symmetries, including both experimental and theoretical aspects. The topics covered were: theoretical descriptions of and constraints on possible violations of CPT and Lorentz symmetry; experimental bounds from measurements on K, B and D mesons; precision comparisons of particle and antiparticle properties (anomalous moments, charge-to-mass ratios, lifetimes, etc.); spectroscopy of hydrogen and antihydrogen; clock-comparison tests; properties of light; etc.