A comatose man is given a fatal dose of insulin in the emergency room, even though he isn't diabetic. An ulcer patient dies of shock after receiving a transfusion of the wrong blood type. A recovering heart patient receives a double dose of medication and suffers a fatal heart attack. Brain surgeon Dr. Tyler Matthews suspects that something is seriously wrong with the hospital's new "Med-InDx" computerized medical record system. But he doesn't suspect that there's something murderously wrong with it. As Matthews begins to peel back the layers of deception that cover the deadly errors, he crosses powerful corporate interests who aren't about to let their multi-billion dollar medical record profits evaporate. Now a target, Matthews finds himself trapped in a maze of deadly conspiracy, with his career, his marriage, and his very life on the line.