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Design and Manufacture of Pharmaceutical Tablets

Autor Reynir Eyjolfsson
en Limba Engleză Paperback – 19 oct 2014
Design and Manufacture of Pharmaceutical Tablets offers real world solutions and outcomes of formulation and processing challenges of pharmaceutical tablets. This book includes numerous practical examples related to actual formulations that have been validated and marketed and covers important data in the areas of stability, dissolution, bioavailibity and processing. It provides important background and theoretical information on design and manufacturing and includes a full section dedicated to design experimental methodology and statistics. In addition, this book offers a a general discussion of excipients used in proper tablet design along with practical examples related to excipients. Drug development scientists in industry and academia, as well as students in the pharmaceutical sciences will greatly benefit from the practical knowledge and case examples provided throughout this book.

  • Incorporates important mathematical models and computational applications
  • Includes unique content on central composite design and augmented simplex lattice
  • Provides background on important design principles with emphasis on quality-based design (QBD) of pharmaceutical dosage forms
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Specificații

ISBN-13: 9780128021828
ISBN-10: 0128021829
Pagini: 68
Ilustrații: colour illustrations
Dimensiuni: 152 x 229 x 4 mm
Greutate: 0.1 kg
Editura: ELSEVIER SCIENCE

Public țintă

Drug formulation and manufacturing scientists in the pharmaceutical industry; academics and professors engaged in research or teaching on tablet design and manufacturing and graduate students in the pharmaceutical sciences taking courses in pharmaceutics

Cuprins

PrefaceAbbreviations
Chapter 1 Introduction
1.1 General Considerations1.2 Particle Sizes1.3 Excipients1.4 Mixing of Pharmaceutical Powders1.5 Statistical Methods1.6 Equipment
Chapter 2 Rapid Release Tablets
2.1 Low dose tablet by Direct Compression2.2 High Dose Tablet by Direct Compression2.3 Insoluble API, Low Dose Tablet by Wet Granulation2.4 Soluble API, Low Dose Tablet by Wet Granulation2.5 Insoluble API, High Dose Tablet by Wet Granulation2.6 Soluble API, High Dose Tablet by Wet Granulation
Chapter 3 Sustained Release (SR) Tablets
3.1 SR Tablet Using a Lipid Release Control Agent3.2 SR Tablet Using HPMC/Eudragit3.3 SR Tablet Using HPMC Mixtures

Recenzii

"...it would be of most benefit to persons with a solid grounding in the theory of pharmaceutical development who are starting to work in the area of solid dosage form design." --The Pharmaceutical Journal, January 2015