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Design & Developement of Floating Tablet of Tolperisone Hydrochloride

Autor Ravi Soni, Mukesh Patel, Natvarlal Patel
en Limba Engleză Paperback – 23 mai 2012
Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2.
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Specificații

ISBN-13: 9783659136061
ISBN-10: 3659136069
Pagini: 160
Dimensiuni: 152 x 229 x 9 mm
Greutate: 0.25 kg
Editura: LAP LAMBERT ACADEMIC PUBLISHING AG & CO KG
Colecția LAP Lambert Academic Publishing

Notă biografică

Ravikumar P. SoniShri B.M. Shah College of Pharmaceutical Education and Research. Education:I received my B. Pharm from Vidya bharti trust college of pharmacy in 2010 (with English), my M. Pharm from Gujarat Technological university in 2012 (with English).