Design of Hybrid Molecules for Drug Development
Editat de Michael Deckeren Limba Engleză Paperback – 10 apr 2017
Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.
With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.
- Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes
- Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied
- Compares the advantages and disadvantages of these compounds
- Includes the very latest developments, such as photoactivatable and photo-responsive drugs
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Specificații
ISBN-13: 9780081010112
ISBN-10: 0081010117
Pagini: 352
Dimensiuni: 191 x 235 x 21 mm
Greutate: 0.61 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0081010117
Pagini: 352
Dimensiuni: 191 x 235 x 21 mm
Greutate: 0.61 kg
Editura: ELSEVIER SCIENCE
Cuprins
1. Introduction
2. Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress
3. Towards Gaseous Mediator Hybrid Drugs
4. Designed Hybrid Compounds for Tropical Parasitic Diseases
5. Dual-Acting Compounds Acting as Receptor Ligands and Enzyme Inhibitors
6. Multitarget Anti-Alzheimer Hybrid Compounds: Do They Work In Vivo?
7. Anticancer Hybrids
8. Molecular Hybridization: An Emerging Tool for the Design of Novel Therapeutics for Alzheimer’s Disease
9. Computational Methods in Multitarget Drug Discovery
10. Medicinal Chemistry of Hybrids for Neurodegenerative Diseases
11. Photoresponsive Hybrid Compounds
2. Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress
3. Towards Gaseous Mediator Hybrid Drugs
4. Designed Hybrid Compounds for Tropical Parasitic Diseases
5. Dual-Acting Compounds Acting as Receptor Ligands and Enzyme Inhibitors
6. Multitarget Anti-Alzheimer Hybrid Compounds: Do They Work In Vivo?
7. Anticancer Hybrids
8. Molecular Hybridization: An Emerging Tool for the Design of Novel Therapeutics for Alzheimer’s Disease
9. Computational Methods in Multitarget Drug Discovery
10. Medicinal Chemistry of Hybrids for Neurodegenerative Diseases
11. Photoresponsive Hybrid Compounds