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Development and Evaluation of Proliposomes-Based Drug Delivery Systems

Autor Sandeep Gupta, Dheeraj Ahirwar, Aditya Nath Pandey
en Limba Engleză Paperback – 17 iun 2012
The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 ± 0.052 µg/cm2/hr as compared to 0.028 ± 0.02 µg/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water.
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Specificații

ISBN-13: 9783659160981
ISBN-10: 3659160989
Pagini: 64
Dimensiuni: 152 x 229 x 4 mm
Greutate: 0.1 kg
Editura: LAP LAMBERT ACADEMIC PUBLISHING AG & CO KG
Colecția LAP Lambert Academic Publishing

Notă biografică

(M. Pharm, Phd)School of Pharmacy, Chouksey Engineering College.