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Development of Osmotically Controlled Drug Delivery System

Autor Shekh Tabasubano, Bhople Amit, Jaiswal Sunil
en Limba Engleză Paperback – 16 mar 2013
Etoricoxib is non steroidal anti-inflammatory drug specifically Cyclooxygenase 2 (COX-2) enzyme inhibitor. Etoricoxib have serious side effect like gastric disturbance, gastric ulceration, gastrointestinal (GIT) bleeding. Conventional drug delivery systems do not have much control over the drug release and effective concentration of drug reach at the target site. It may lead to unsteady plasma drug level result into adverse effect due to plasma drug level crossing therapeutic window and undertherparutic response because of plasma drug level below therapeutic window. GIT side effect of Etoricoxib due to unsteady plasma drug level when administered in conventional dosage form. Development of elementary osmotic pump for etoricoxib release the drug in controlled fashion by zero order result in mentainance of constant plasma drug level for long period of time lead to diminished serious GIT side effect of etoricoxib.
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Specificații

ISBN-13: 9783659370519
ISBN-10: 3659370517
Pagini: 80
Dimensiuni: 152 x 229 x 5 mm
Greutate: 0.13 kg
Editura: LAP Lambert Academic Publishing AG & Co. KG
Colecția LAP Lambert Academic Publishing

Notă biografică

Ms. Tabasubano Shekh has obtained her graduation in Pharmacy i.e. B.Pharm. Her main area of research are Novel Drug Delivery System in particular the Osmotically Controlled Drug Delivery System. She has Industrial experience in Drug Regulatory Affaires Department. She Published number of research and review papers in various journals.