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Developmental and Reproductive Toxicology: A Practical Approach, Third Edition

Editat de Ronald D Hood
en Limba Engleză Hardback – 14 dec 2011
The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU’s REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics.
The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches.
Developmental and Reproductive Toxicology, Third Edition:
  • Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies.
  • Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity.
  • Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference.
  • Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment.
This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

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Specificații

ISBN-13: 9781841847771
ISBN-10: 1841847771
Pagini: 870
Ilustrații: 177 b/w images, 117 tables, 16 halftones and 161 line drawings
Dimensiuni: 189 x 246 x 32 mm
Greutate: 2.02 kg
Ediția:Revizuită
Editura: CRC Press
Colecția CRC Press

Public țintă

Professional and Professional Reference

Cuprins

PRINCIPLES AND MECHANISMS. Principles of Developmental Toxicology. Mechanisms of Developmental Toxicology. Pathogenesis of Abnormal Development. Maternally-Mediated Effects on Development. Paternally-Mediated Effects on Development. Comparative Embryology. HAZARD ASSESSMENT. Developmental Toxicity Testing - Single and Multiple Generation Test Methodology. Nonclinical Juvenile Toxicity Testing -- Methodology and Data Evaluation. Testing for Reproductive Toxicity in the Male and Female and Evaluation of the Data. Endocrine Disruption - Testing and Data Evaluation. Role of Xenobiotic Metabolism in Developmental Toxicity. Toxicokinetics. Cellular, Biochemical, and Molecular Techniques. Genomics and Proteomics. In Vitro Mechanistic Studies. Statistical Analysis. Quality Control - GLP for Toxicologists. Regulatory Test Guidelines. Epidemiologic Techniques in Development and Reproductive Toxicology. Risk Assessment - EPA Approach. Risk Assessment - FDA Approach. Appendices.

Notă biografică

Ronald D. Hood is a Toxicology Consultant at Ronald D. Hood & Associates and works at the University of Alabama, Tuscaloosa, USA.

Recenzii

"This is a great foundation book for trainees pursuing research in reproductive toxicology and serves as the perfect reference during the course of study. The field of reproductive toxicology is changing and this update is critical and mostly timely."
Doody's Review Service
"It is one of the most comprehensive and definitive publications in the field and should be a mandatory addition to the libraries of students, researchers, and regulators alike in the field of reproductive and developmental toxicology."
International Journal of Toxicology

Descriere

A practical guide to developmental and reproductive toxicology in a regulatory environment, the third edition of this volume provides a comprehensive update of current chapters to reflect recent changes in the field. The book examines the use and interpretation of the newest research techniques, such as functional genomics and proteomics, as well as traditional approaches. It also discusses conducting tests and interpreting data in areas such as nonclinical juvenile toxicity testing, endocrine modulation, and toxicokinetics.