Degradation of the joints is medically termed as osteoarthritis. Millions of people across the globe are affected by the extremely debilitating disease of osteoarthritis (OA). No disease modifying drug approved by FDA is currently available for this disease in particular. Surgery continues to be an efficient final solution to restore the function of the joints. The increase in the amount of aging populations across the world over the past few years has consequently increased the number of OA patients significantly with estimations of further increase in the near future. This book presents latest developments in diagnosis, treatment and surgery of OA, covering a broad spectrum of topics like alternative medicine and cutting edge gene therapy. Integrative approaches are required for formulation of new and efficient therapies to cure OA in the future. Various surgical methodologies have been elucidated in this book for the restoration of the function of the joints. Also, several treatment options have been discussed, in order to decrease the pain and improve the quality of life of the OA patients.