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Disulfiram and Its Metabolite, Diethyldithiocarbamate de Gessner, Peter K.

Disulfiram and Its Metabolite, Diethyldithiocarbamate

Autor Gessner, Peter K., Gessner, P. K., Gessner
en Limba Engleză Hardback
This book provides a critical review of the current state of research on the properties, pharmacology and toxicology of disulfiram and diethyldithiocarbamate and their use for the treatment of a variety of human disease conditions, including cancer, alcoholism and heavy metal toxification.
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Specificații

ISBN-13: 9780412360107
ISBN-10: 0412360101
Pagini: 452
Greutate: 0.84 kg

Cuprins

Introduction and scope of monograph. Relevant chemical and physical properties. Reactions of disulfiram and diethyldithiocarbamate with blood constituents. Assay methods for disulfiram and metabolites in biological materials. Metabolism of disulfiram and diethyldithiocarbamate. Pharmacokinetic aspects of the disposition of disulfiram and metabolites. Heavy metals: effects of diethyldithiocarbamate and disulfiram administration. Disulfiram and diethyldithiocarbamate as enzyme inhibitors. Inhibition of aldehyde dehydrogenase. The disulfiram-ethanol reaction. Disulfiram therapy of alcohol abuse. Various biological phenomena. Immunomodulatory actions of diethyldithiocarbamate. Clinical status of diethyldithiocarbamate as an immunostimulant. Modulation of various biological phenomena. Modulation of cancer chemotherapy. Toxicology. Bibliography. Index.