DNA Repair and Recombination
Autor T. R. Lindahl, Lindahl Editat de S.C. Westen Limba Engleză Hardback – 30 iun 1995
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Specificații
ISBN-13: 9780412640407
ISBN-10: 0412640406
Pagini: 103
Dimensiuni: 213 x 303 x 13 mm
Greutate: 0.6 kg
Editura: Kluwer Academic Publishers
Locul publicării:Dordrecht, Netherlands
ISBN-10: 0412640406
Pagini: 103
Dimensiuni: 213 x 303 x 13 mm
Greutate: 0.6 kg
Editura: Kluwer Academic Publishers
Locul publicării:Dordrecht, Netherlands
Public țintă
ResearchCuprins
RecA protein mediates homologous recognition via non-Watson-Crick bonds in base triplets. The initiation and control of homologous recombination in Escherichia coli. Formation, translocation and resolution of Holliday junctions during homologous genetic recombination. Structure of the four-way DNA junction and its interaction with proteins. Site Specific recombination and circular chromosome segregation. Steps along the pathway of V(D)J recombination. Regulation and mechanisms of gene amplification. Enzymes acting at strand interruptions in DNA. Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription. Proteins that participate in nucleotide excision repair of DNA in mammalian cells. Nucleotide excision repair syndromes: molecular basis and clinical symptoms. On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage. Mismatch repair, genetic stability and tumour avoidance. Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans.
Recenzii
...the whole book which provides an excellent starting point for anyone interested in these topics. - Heredity
Textul de pe ultima copertă
In this book, which was generated from a Royal Society discussion meeting, leading international researchers provide a current and authoritative account of all aspects of DNA repair and recombination, from bacteria to humans. It is a timely volume, particularly in view of the revelation that the biochemical pathways of repair and recombination in prokaryotes and lower eukaryotes have been conserved in human cells. There is now much exciting research into understanding the molecular mechanisms of repair and recombination in higher eukaryotes.