DNA Repair and Replication: Mechanisms and Clinical Significance
Editat de Roger J. A. Grand, John J. Reynoldsen Limba Engleză Hardback – 4 sep 2018
Key Selling Features:
- Chapters written by leading researchers
- Includes description of replication processes, causes of damage, and methods of repair
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Specificații
ISBN-13: 9781138612914
ISBN-10: 113861291X
Pagini: 364
Dimensiuni: 210 x 280 x 25 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția Garland Science
ISBN-10: 113861291X
Pagini: 364
Dimensiuni: 210 x 280 x 25 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția Garland Science
Public țintă
Postgraduate, Professional, and UndergraduateCuprins
Preface
Editors
Contributors
1. Introduction
John J. Reynolds, Roger J. A. Grand, and Martin R. Higgs
2. DNA Replication and Cell Cycle Control
Sara Priego Moreno, Rebecca M. Jones, and Agnieszka Gambus
3. DNA Replication Termination and Genomic Instability
Rebecca M. Jones, Sara Priego Moreno, and Agnieszka Gambus
4. Mechanisms of DNA Damage Tolerance
Cyrus Vaziri and Anastasia Zlatanou
5. The Repair of DNA Single-Strand Breaks and DNA Adducts: Mechanisms and Links to Human Disease
Alicja Winczura and John J. Reynolds
6. Homologous Recombination at Replication Forks
Eva Petermann
7. Mechanism of Double-Strand Break Repair by Non-Homologous End Joining
Michal Malewicz
8. Protein Methylation and the DNA Damage Response
Martin R. Higgs and Clare Davies
9. Ubiquitin, SUMO and the DNA Double-Strand Break Response
Ruth M. Densham, Alexander J. Garvin, and Joanna R. Morris
10. Transcription in the Context of Genome Stability Maintenance
Marco Saponaro
11. RNA Binding Proteins and the DNA Damage Response
Roger J. A. Grand
12. DNA Replication and Inherited Human Disease
John J. Reynolds and Grant S. Stewart
13. Ataxia Telangiectasia and Ataxia Telangiectasia–Like Disorders
A. Malcolm R. Taylor
14. DNA Repair Mechanisms in Stem Cells and Implications during Ageing
Rachel Bayley and Paloma Garcia
15. Targeting Replication Stress in Sporadic Tumours
Marwan Kwok and Tatjana Stankovic
16. A Few of the Many Outstanding Questions
John J. Reynolds and Roger J. A. Grand
Index
Editors
Contributors
1. Introduction
John J. Reynolds, Roger J. A. Grand, and Martin R. Higgs
2. DNA Replication and Cell Cycle Control
Sara Priego Moreno, Rebecca M. Jones, and Agnieszka Gambus
3. DNA Replication Termination and Genomic Instability
Rebecca M. Jones, Sara Priego Moreno, and Agnieszka Gambus
4. Mechanisms of DNA Damage Tolerance
Cyrus Vaziri and Anastasia Zlatanou
5. The Repair of DNA Single-Strand Breaks and DNA Adducts: Mechanisms and Links to Human Disease
Alicja Winczura and John J. Reynolds
6. Homologous Recombination at Replication Forks
Eva Petermann
7. Mechanism of Double-Strand Break Repair by Non-Homologous End Joining
Michal Malewicz
8. Protein Methylation and the DNA Damage Response
Martin R. Higgs and Clare Davies
9. Ubiquitin, SUMO and the DNA Double-Strand Break Response
Ruth M. Densham, Alexander J. Garvin, and Joanna R. Morris
10. Transcription in the Context of Genome Stability Maintenance
Marco Saponaro
11. RNA Binding Proteins and the DNA Damage Response
Roger J. A. Grand
12. DNA Replication and Inherited Human Disease
John J. Reynolds and Grant S. Stewart
13. Ataxia Telangiectasia and Ataxia Telangiectasia–Like Disorders
A. Malcolm R. Taylor
14. DNA Repair Mechanisms in Stem Cells and Implications during Ageing
Rachel Bayley and Paloma Garcia
15. Targeting Replication Stress in Sporadic Tumours
Marwan Kwok and Tatjana Stankovic
16. A Few of the Many Outstanding Questions
John J. Reynolds and Roger J. A. Grand
Index
Notă biografică
Dr Roger J. A. Grand was an undergraduate in biochemistry at the University of Sheffield, followed by a PhD at the University of Leeds. After a fellowship at Royal Holloway College, University of London, he moved to the Department of Biochemistry at the University of Birmingham to study proteins involved in the regulation of striated muscle contraction. This research helped to define how signals were transmitted through the troponin complex to initiate muscle contraction. After a few years, Roger joined the Department of Cancer Sciences, which later became the Institute for Cancer and Genomic Sciences, at the University of Birmingham. Roger Grand, is now a Reader in Experimental Cancer Sciences, and leads a research group specialising in the study of various aspects of the DNA damage response, both in normal cells and in those undergoing viral infection. Most recently, his lab has been interested in rare inherited diseases linked to mutations in DNA repair proteins.
Dr John J. Reynoldsearned a degree in genetics and microbiology at the University of Sheffield followed by doctoral research at the Genome Damage and Stability Centre (University of Sussex), where he worked on characterising the molecular defects underlying rare human diseases caused by mutations in DNA single-strand break repair factors. His post-doctoral research at the Cancer and Genomic Sciences (University of Birmingham) has focused on identifying and characterising novel DNA damage response genes, and investigating how defects in DNA repair and DNA replication factors give rise to human diseases, such as microcephalic dwarfism.
Dr John J. Reynoldsearned a degree in genetics and microbiology at the University of Sheffield followed by doctoral research at the Genome Damage and Stability Centre (University of Sussex), where he worked on characterising the molecular defects underlying rare human diseases caused by mutations in DNA single-strand break repair factors. His post-doctoral research at the Cancer and Genomic Sciences (University of Birmingham) has focused on identifying and characterising novel DNA damage response genes, and investigating how defects in DNA repair and DNA replication factors give rise to human diseases, such as microcephalic dwarfism.
Descriere
DNA Repair and Replication is a contributed text written by active researchers. A number of diseases associated with DNA replication and repair will also be included, as will the significance for treatment. This book will discuss the areas where DNA replication, DNA repair, and human diseases overlap.