Cantitate/Preț
Produs

Drug Taratogenecity (Enalapril)

Autor Sharif Aasia
en Limba Engleză Paperback – 24 iul 2012
In the present study, Enalapril was tested for its teratogenic effects on the developing mice. For this purpose different concentration 0.2, 0.4 and 0.8 µg\g B.W. were prepared. These doses were given to the pregnant mice orally on days 6-12 of gestation once in a day. The treated mice were anaesthetized on day 15th of gestation and fetuses were taken out and weighed. The recovered fetuses were fixed in Bouin's fixative and then preserve in 70% alcohol. The morphological analysis showed that developmental defects such as dysplasia of hindlimb, micromelia, webbed shaped manus and pes, club shaped pes, syndactyly, kinky tail, intrauterine growth retardation, lesions on skin, hemorrhagic spots, omphalocele and resorbed fetuses were also observed. Morphometric observation showed a significant (p<0.001) decrease in mean fetal body weight, crown-rump length, head and eye circumference, forelimb, hindlimb and tail length of the fetuses as compared to control. These results indicate that Enalapril is dangerous to developing mice fetuses, which may be equally harmful for the human development too. It is quite apparent that Enalapril should not be given to pregnant mothers.
Citește tot Restrânge

Preț: 31765 lei

Nou

Puncte Express: 476

Preț estimativ în valută:
6082 6333$ 5046£

Carte tipărită la comandă

Livrare economică 14-28 februarie

Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783659191503
ISBN-10: 3659191507
Pagini: 80
Dimensiuni: 152 x 229 x 5 mm
Greutate: 0.13 kg
Editura: LAP Lambert Academic Publishing AG & Co. KG
Colecția LAP Lambert Academic Publishing

Notă biografică

Aasia Sharif M.philUniversity of the Punjab Aasia Sharif,PhD scholar In Department of Zoology, University of the Punjab, working in the field of Endocrinology/Physiology. She has been selected by Higher Education Commission Pakistan for indigenous scholarship.She has experience of research work in the field of Teratologyand Fisheries.