Low birth weight newborns have been one of the most important problems in many countries. Early intervention (EI) is a set of programs for children with developmental problems. Since 2010 in Villa Clara, this program is being applied in a differentiated way in neonates under 1500 grams.a prospective descriptive observational study was carried out on neonates with very low birth weight who underwent an early care program in the Neonatology Service of the "Mariana Grajales" University Hospital of Santa Clara between January and December 2010, with the aim of assessing the results obtained and the repercussion on the neurodevelopment of these patients in the first 3 months of life.