This book is about doing innovative research to achieve sustainable and equitable change in people’s health and well-being through improved interactions with the environment. It presents experiences from the field of ecosystem approaches to health (or ecohealth research) and some insights and lessons learned. It builds on previous literature, notably Forget (1997), Forget and Lebel (2001), Lebel (2003), and Waltner-Toews et al. (2008). Through case-studies and other contributions by researchers supported by Canada’s International Development Research Centre (IDRC), the book presents evidence of real changes in conditions of people, their health, and the ecosystems that support them. These changes were derived from applications of an ecosystem approach to health in developing regions of the world. The book also illustrates the resulting body of applied, participatory, and action research that improved health and environmental management in developing countries and, in many cases, influenced policies and practices.