Hypertension is a clinical condition that involves several factors such as inflammation, oxidative stress and endothelial dysfunction. Intravenous laser blood irradiation (ILIB) has been used lately by physiotherapists in the treatment and prevention of cardiovascular diseases due to its effects on the system, such as antioxidant, anti-inflammatory, haemostatic balance and others. The aim of this research was to investigate the effects of intravenous laser irradiation of blood in patients with systemic arterial hypertension. In this experimental, prospective and descriptive study, 5 women participated, randomly divided into two groups: Laser Group (n=03) and Sham Group (n=02). A total of 10 sessions were performed on alternate days with ILIB applications in the radial artery of the dominant limb, with a 20-day interval after the 5th session for subsequent reapplication (5 more alternate sessions). The group submitted to intravascular blood irradiation with laser showed a greater reduction in blood pressure values compared to the SG and, therefore, ILIB was effective in reducing BP in hypertensive women.