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Effects of new onset diabetes and dyslipidemia on the allograft

Autor Borda Bernadett
en Limba Engleză Paperback – apr 2013
The principal risk factors for cardiovascular mortality posttransplantation are hyperglycemia, hypertriglyceridemia, obesity, and smoking. We assessed the risk factors for new-onset diabetes and dyslipidemia and their effects on the function and histopathologic changes in the allografts at 1 year posttransplantation. In regard to immunosuppressive therapy, new onset diabetes mellitus was significantly more frequent among patients prescribed tacrolimus, whereas subjects who received cyclosporine A showed a significantly higher incidence of dyslipidemia. In regard to allograft function, a significant difference was noted at year 1 after transplantation. When assessing morphologic changes in the kidney, we observed significantly more frequent interstitial fibrosis/tubular atrophy in all 3 groups compared with normal function patients. Our clinical study suggested that at year 1 after transplantation the allograft function is already impaired in the presence of both medical conditions (diabetes and dyslipidemia). However, in regard to morphology, a single condition (diabetes or dyslipidemia) is sufficient to produce histologic changes in the kidney.
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Specificații

ISBN-13: 9783659378577
ISBN-10: 3659378577
Pagini: 52
Dimensiuni: 152 x 229 x 3 mm
Greutate: 0.09 kg
Editura: LAP Lambert Academic Publishing AG & Co. KG
Colecția LAP Lambert Academic Publishing

Notă biografică

Bernadett Borda has worked at the Department of Surgery University of Szeged. She obtained Ph.D degree in 2011. Her field of research is new onset diabetes mellitus after kidney transplantation and effect on the allograft.