1898. Picasso is set in Horta de Sant Joan, a rural town where hell live a mysterious initiatory adventure and will make a discovery that will change his live forever and also the culture of the twentieth century. Leo Vidal, a journalist, accepts the commission of a wealthy gallery owner in Sitges: to track the whereabouts of a painting bequeathed to his host by Picasso himself in Horta de Sant Joan a century ago. This work is noted in the biographies of the painter and has never been found, which has generated all kinds of interpretations. However, the investigation will soon become into a race full of dangers and revelations.