This issue of Emergency Medicine Clinics, guest edited by Joshua Joseph and Benjamin White, focuses on Emergency Department Operations and Administration. Topics include: Emergency Department Operations Overview; Queuing Theory and Modeling ED Resource Utilization; Factors Affecting ED Crowding; Staffing and Provider Productivity in the ED; Patient Assignment Models in the ED; ED Layout and Organization; Lean Processes in the ED; ED Observation and Alternatives to Admission; Quality Assurance in the ED; Information Management in the ED; Best Practices in Communication and Patient Safety; Optimizing Patient Experience in the ED; Management of the Academic ED; and Strategies for Provider Well-being in the ED.