Endothelin Receptors and Signaling Mechanisms

1. Introduction to the Endothelin System.- 2. Endothelin Receptors and Receptor Antagonists.- 3. Novel Endothelin Receptors.- 4. “Sticky” Conundrums in the Endothelin System: Unique Binding Characteristics of Receptor Agonists and Antagonists.- 5. Functional Coordination and Cooperation Between Endothelin and Nitric Oxide Systems in Vascular Regulation.- 6. Molecular and Structural Biology of Endothelin Receptors.- 7. Cytokine Regulation of Endothelin Action.- 8. Endothelin Modulation of Renal Sodium and Water Transport.- 9. Endothelin and Ion Channels.- 10. Endothelin and Calcium Signaling.- 11. Endothelin Regulation of Cardiac Contractility: Signal Transduction Pathways.- 12. Endothelin Signaling to the Nucleus: Regulation of Gene Expression and Phenotype.- 13. Mechanisms of Endothelin-induced Mitogenesis and Activation of Stress Response Protein Kinases.- Color Insert.