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Enzybiotics – Antibiotic Enzymes as Drugs and Therapeutics

Autor TG Villa
en Limba Engleză Hardback – 25 ian 2010
Presents the latest research and applications for a new, promising approach to fighting infectious diseases Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications. The book begins with four chapters that review the potential applications, possible advantages, and phylogeny of enzybiotics. Next, the book explores: * A new approach to controlling infections using Gram-negative bacteria * Bacteriophage holins and their membrane-disrupting activity * Anti-staphylococcal lytic enzymes * Membrane-targeted enzybiotics * Design of phage cocktails for therapy from a host-range point of view * Novel methods to identify new enzybiotics * Genetically modified phages that deliver suicidal genes to target bacteria The authors, all active enzybiotics researchers, offer a variety of perspectives, the benefit of their own hands-on investigations, as well as a thorough review and analysis of the current literature. As more and more bacteria become resistant to antibiotics, the development of new disease-fighting agents has become essential. This book demonstrates the full potential of the emerging field of enzybiotics to control infectious diseases. Moreover, it will serve as a springboard for new research and the development of new therapeutics.
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Specificații

ISBN-13: 9780470376553
ISBN-10: 0470376554
Pagini: 284
Dimensiuni: 161 x 241 x 24 mm
Greutate: 0.59 kg
Editura: Wiley
Locul publicării:Hoboken, United States

Public țintă

Pharmaceutical scientists, antibacterial drug developers, medicinal chemists, microbiologists, biochemists, molecular biologists, infectious disease specialists

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Descriere

Enzybiotics, by using enzymes to fight bacteria, offer a novel and promising new way to combat infectious diseases. This book presents the state-of-the-art and therapeutic potential of enzybiotics, with a stress on therapeutic applications. The coverage offers a unique combination of medicinal chemistry, microbiology, genetics, and biochemistry.