Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging
Autor Albert Stuart Reece, Gary Kenneth Hulseen Limba Engleză Paperback – mar 2025
With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.
- Examines adult and pediatric neurotoxicity and genotoxicity from cannabis use, along with health impacts
- Analyzes epigenetics and the observed pattern of teratological, cancerogenic, and age-accelerated disease
- Utilizes advanced statistical and geotemporalspatial analysis to investigate cannabis exposure and health
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Specificații
ISBN-13: 9780443134920
ISBN-10: 0443134928
Pagini: 1150
Dimensiuni: 216 x 276 mm
Greutate: 0.45 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0443134928
Pagini: 1150
Dimensiuni: 216 x 276 mm
Greutate: 0.45 kg
Editura: ELSEVIER SCIENCE
Public țintă
Researchers and epidemiologists studying the neurotoxic and genotoxic health impact of cannabis including neurological aspects of long-term use of cannabis usage and cannabis related cancers .Industry professionals and clinicians interested in epidemiology of addiction, genetics, and neurologyCuprins
SECTION 1: Mental Illness Close Parallels between Cannabis Use and Deteriorating US Mental Health at Four Levels Supports and Extends the Epidemiological Salience of Demonstrated Causal Mental Health Relationships: A Geospatiotemporal Study
1. National Trends
2. Regional Trends
3. State Trends
4. Sub-State Trends
5. Geospatial Analysis
6. Causality Criteria
SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011.
7. National Trends
8. Regional Trends
9. State Trends
10. Geospatial Analysis
11. Changes in State Trends
12. Legal Status and Autism
13. Geospatial Analysis of Legal Status and Autism
SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity
14. Drug Use by Race
15. Drugs and Defects Overview
16. Chromosomal Anomalies: Anomalies 1:5
17. Gastroschisis: Anomaly 6
18. Atrial Septal Defect (Secundum): Anomaly 7
19. Cardiovascular Defects of Interest: Anomalies 8-11
20. Hawaiian - American Review: Anomalies 12-37
21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality
SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses
22. General Introduction and Overview
23. Sequential Analysis of Cancer Types
24. Geospatiotemporal Modelling - Fitted Values
25. Geospatiotemporal Modelling - Matrix Multiplication
26. Summary of Geospatiotemporal Modelling
27. Overall Conclusions
SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail.
28. Epigenetics of Cannabinoids - Introduction
29. Epigenetics of Cannabinoids – Historical Studies
30. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Overview
31. Epigenetics of Cannabinoids – Longitudinal Sperm Study – Stem Cells
32. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Chromosomes
33. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology - Brain
34. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology - Cardiovasculature
35. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology – Other Organs
36. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Carcinogenesis
37. Epigenetics of Cannabinoids – Accelerated Aging
1. National Trends
2. Regional Trends
3. State Trends
4. Sub-State Trends
5. Geospatial Analysis
6. Causality Criteria
SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011.
7. National Trends
8. Regional Trends
9. State Trends
10. Geospatial Analysis
11. Changes in State Trends
12. Legal Status and Autism
13. Geospatial Analysis of Legal Status and Autism
SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity
14. Drug Use by Race
15. Drugs and Defects Overview
16. Chromosomal Anomalies: Anomalies 1:5
17. Gastroschisis: Anomaly 6
18. Atrial Septal Defect (Secundum): Anomaly 7
19. Cardiovascular Defects of Interest: Anomalies 8-11
20. Hawaiian - American Review: Anomalies 12-37
21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality
SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses
22. General Introduction and Overview
23. Sequential Analysis of Cancer Types
24. Geospatiotemporal Modelling - Fitted Values
25. Geospatiotemporal Modelling - Matrix Multiplication
26. Summary of Geospatiotemporal Modelling
27. Overall Conclusions
SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail.
28. Epigenetics of Cannabinoids - Introduction
29. Epigenetics of Cannabinoids – Historical Studies
30. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Overview
31. Epigenetics of Cannabinoids – Longitudinal Sperm Study – Stem Cells
32. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Chromosomes
33. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology - Brain
34. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology - Cardiovasculature
35. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology – Other Organs
36. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Carcinogenesis
37. Epigenetics of Cannabinoids – Accelerated Aging