This book covers multiple topics of Ergonomics following a systems approach, analysing the relationships between workers and their work environment from different but complementary standpoints. The chapters focused on Physical Ergonomics address the topics upper and lower limbs as well as low back musculoskeletal disorders and some methodologies and tools that can be used to tackle them. The organizational aspects of work are the subject of a chapter that discusses how dynamic, flexible and reconfigurable assembly systems can adequately respond to changes in the market. The chapters focused on Human-Computer Interaction discuss the topics of Usability, User-Centred Design and User Experience Design presenting framework concepts for the usability engineering life cycle aiming to improve the user-system interaction, for instance of automated control systems. Cognitive Ergonomics is addressed in the book discussing the critical thinking skills and how people engage in cognitive work.