The issue of geopolitical networks in the Mediterranean has been the subject of much lively debate in recent years. In the framework of a program funded by the French National Research Agency, a program consisting of philologists, historians, archaeologists and geologists took a model of integration into the larger whole of the Mediterranean the ancient regions of Caria and Lycia. At the end of this program, a symposium held in Bordeaux provided an update on the progress of our knowledge of indigenous languages, foreign influences in the architecture and funerary practices. In turn, recent archaeological and epigraphic discoveries as well as historical developments underlying them shed light on the dynamism and ability of Caria and Lycia to adapt to political changes in the Mediterranean world.