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Extracellular Vesicle-Based Therapeutics

Editat de Tushar Patel
en Limba Engleză Paperback – 30 sep 2022
Extracellular Vesicles-Based Therapeutics presents the exciting prospect of targeted delivery of drugs through exosomes. Taking a critical perspective, the Editor gathered worldwide experts both in academia and corporate settings to cover all aspects of the subject, from fundamental biological aspects to scaling up production, and regulation.
The book is structured in six sections, each covering a distinct topic. Within each section, the authors and chapters were selected to provide a balanced coverage. Section I deals with the fundamentals of EV biology: types, formation, interactions and effects. Section II covers Extracellular Vesicles (EVs) isolation, and purification approaches. Section III presents EV production platforms, providing a framework and guidelines by which clinically usable and consistent EV therapeutics could be manufactured. Section IV covers preclinical studies and applications, reviewing studies that provide opportunities to identify disease-relevant indications for EV therapeutics and to guide their translation to clinical trials. Section V presents drug development and commercialization of EV therapeutics, covering considerations in regulatory approvals and market access for EV based therapeutics. Section VI covers clinical trials of EV therapeutics, outlining a framework for clinical evaluation, including study design and clinical trials strategies and examples of on-going trials of EV-based therapeutics.
Extracellular Vesicles-Based Therapeutics is a complete resource for researchers in this exciting area. Its breadth of coverage makes it particularly interesting to pharmaceutical researchers exploring the potential of this platform for targeted drug delivery. Physicians, Regulators, Laboratory directors and Industry executives in biotechnology would also benefit from the contents in this book.


  • Offers a critical view into the potential use of Exosomes for therapeutic use
  • Brings experts in academic and industry together to cover biological principles all the way to manufacturing
  • Strong translational characteristics, taking research to practice
  • Covers scaling up processes and regulation
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Specificații

ISBN-13: 9780323902755
ISBN-10: 0323902758
Pagini: 366
Ilustrații: Approx. 100 illustrations (50 in full color)
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE

Cuprins

Section 1: Fundamentals of EV biology: types, formation, interactions and effects
Section 2: EV isolation, and purification
Section 3: EV production platforms
Section 4: Preclinical studies and applications
Section 5: Drug development and commercialization of EV therapeutics
Section 6: Clinical trials of EV therapeutics