This volume aims to take up the theme of the relationship between faith and pestilence, which, despite its topicality, is rooted in a long-term dimension that involves different areas of knowledge. A markedly disciplinary look brings together historical, theological, political, and juridical analyses and thus allows us to understand this relationship through paradigms, turning points, continuity and discontinuity. In this way, it becomes possible to observe how the theme has crossed ages and religions, from the fathers of the church, to medicine in medieval Islam, up to contemporary times, with Ivan Illich's harsh critique of forced medicalization and the issues that emerged during the COVID-19 pandemic.