FIBROBLAST GROWTH FACTORS
Autor Michael Simonsen Limba Engleză Hardback – 27 dec 2016
Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.
With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments -- endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.
It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.
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Specificații
ISBN-13: 9789813143364
ISBN-10: 9813143363
Pagini: 284
Dimensiuni: 157 x 235 x 20 mm
Greutate: 0.55 kg
Editura: World Scientific
ISBN-10: 9813143363
Pagini: 284
Dimensiuni: 157 x 235 x 20 mm
Greutate: 0.55 kg
Editura: World Scientific