Oral medicines are the usual method of treatment, because of their benefits, comfort in the administration of oral medicine, favored patients, economical efficacy and facility of large scale manufacture. Approximately 60% of currently available medicinal molecules are given via mouth. It is estimated nowadays that oral formulations account for about 90% of the worldwide market share of all human drug formulations. About 84% of best-selling medications, now worth 35 billion dollars, with an annual growth rate of 10%. Patients are often more likely than other parenteral methods to intravenous, subcutaneous, intramuscular and asthma injections. Oral wording is moreover; medicinal products given via oral procedure may cure pathological local illnesses such as colorectal abdomen, malignancies, infections, inflammation, bowel diseases, Gastroduodenum ulcers and reflux issues. [1-5] However, it is difficult to create oral formulations primarily because to the physicochemical characteristics of medications, including low solubility and membrane permeability. The absorption of therapeutic drugs may also be reduced by the detection of a low degree of biological and chemical stability and physiological barriers such as pH, effect transportation and metabolism. In addition, certain medicines in the local region may lead to nausea and discomfort. Over the past four decades.