Francine Vaccine is a light hearted kids rhyming story that introduces children to the concept of vaccination through Francine the protagonist. Francine's organ friends plan a party for her birthday and everyone is having a great time, until germs crash the party. They break everything in the house, eat all the food and push the organ friends aside. Francine gets the organs to band together and fight off the germs and sweep them out of the house before they can cause more damage. They then fix up the house, order in pizza and continue having fun together.