Free Radicals and Inhalation Pathology: Respiratory System, Mononuclear Phagocyte System Hypoxia and Reoxygenation Pneumoconioses and other Granulomatoses Cancer

History and Scientific Background.- Protagonists of Industrial Medicine.- Aetiopathogenesis of Pulmonary Fibrosis and Malignancy.- Formulation of the Problems.- Material and Methods.- Reactive Oxygen and Nitrogen Species.- Respiratory System: Orthology and Pathology.- Tracheo-bronchial Epithelium.- Pneumocytes.- Alveolar Macrophages.- Interstice.- Pulmonary Blood Vessels.- Pulmonary Lymphatic Vessels.- Pulmonary Nerves.- Radical-Mediated Pulmonary Lesions.- Extrapulmonary Targets.- Radical Damage in Nonrespiratory Organ Systems.- Ageing.- Molecular Ageing.- Ageing of Organs.- Possible Strategies to Prevent and Reverse Manifestations of Ageing.- Cancer.- Carcinogenesis.- Tumour Proliferation and Metastasis.- Antitumour Drug Therapy.

 
This book summarizes highlights in the field of free radicals in medicine and biology, with a detailed analysis of the extensive recent literature.  It describes results from experimental research work on dust inhalation, hypoxia, and environmental toxicology using  morphologic methods such as electron microscopy, interference microscopy and time-lapse techniques in tissue cultures.  It also  discusses free radical reactions that are probably involved in the pathogenesis of both physical and chemical environmental hazards and provides a list of  radical scavengers that are useful prophylatic agents  in case of unavoidable exposure. A short history of dust diseases that have challenged mankind since prehistoric times serves as an introduction to this comprehensive treatise.  It is hoped that by covering this field in one monograph, adding light will be shed on the important role of both oxygen- and nitrogen-centered radicals in disease pathogenesis, a role that is receiving increasing recognition. The CD-ROM included  with this volume lists nearly 25,000 literature citations useful as a  reference source for  researches, clinicians and students.

In view of the ever growing interest in free radicals and radical scavenging this book offers: encyclopedic information a comprehensive overview on prophylactic agents a full range of impressive electron-microscopic illustrations full coverage of the recent literature on an enclosed CD-ROM