Ischemia-reperfusion injury is the major cause of organ dysfunction especially in cardiovascular diseases; therefore, experimental techniques to induce myocardial ischemia-reperfusion injury are necessary to understand the basic pathophysiology of cardiovascular-related disorders. The present book attempts to illustrate the basic and fundamental aspects of ischemia-reperfusion injury in preclinical and clinical studies. The key features of this book are various experimental techniques to induce myocardial ischemia-reperfusion injury, various parameters to assess myocardial injury, therapeutic approaches to limit ischemia-reperfusion injury.