GABA: Receptors, Transporters and Metabolism de Chikako Tanaka

GABA: Receptors, Transporters and Metabolism: Advances in Pharmacological Sciences

Chikako Tanaka

Norman G. Bowery

Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.

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Cuprins

Opening lecture.- Establishment of GABA as an inhibitory neurotransmitter at Crustacean neuromuscular junction and in the mammalian central nervous system.- Glutamate decarboxylase and autoimmunity.- Physiological aspects of GAD-GABA system in the pancreatic islet.- Membrane associated L-glutamate decarboxylase and insulin-dependent diabetes mellitus (IDDM).- Glutamate decarboxylase, GABA and autoimmunity.- Stiff-Man syndrome and glutamic acid decarboxylase: An updated view.- Anti-GAD antibody in various neurological diseases.- Molecular structure and functional regulation of GAGA transporters.- GABA transporters: Structure, function and mechanism.- Heterogeneity of brain GABA transporters.- Developmental expression of the GABA transporter GAT4.- Functional regulation of GABA transporters by PKC and their distinct localization.- Transmitter release and GABA receptor regulation.- GABAB receptor control of transmitter release in the spinal cord.- Role of GABAA and GABAB receptors in calcium homeostasis and transmitter release in cerebellar granule neurons.- Interactions between endogenous L-DOPA and GABAA systems for cardiovascular control in the rat nucleus Tractus solitarii.- Potentiation by protein kinase C activation of GABA release from Xenopus oocytes injected with rat brain mRNA.- GABA receptor subtypes and functional regulation.- The molecular biology of GABAA receptors and its applications.- Modelling functional domains of the GABAA receptor chloride channel.- GABAA receptor subtypes: Pharmacological significance and mutational analysis in vivo.- Regulation of GABAA receptors by multiple protein kinases.- Enhancement of GABA-induced current by 20-hydroxyecdysone in cultured cortical neurons.- Differential sensitivity during development of GABA-mediated synaptic transmission to a neuroactive steroid in rat hippocampus and cerebellum.- Ontogenic changes of GABAA function of the rat Meynert neuron.- GABAergic system modulates the formation of LTP (long-term potentiation) in the superior colliculus.- GABA receptor-chloride channel complex as a target site of alcohol.- Functional analysis on GABAB receptor using a reconstituted system with purified GABAB receptor, Gi/Go protein and adenylyl cyclase.- Paradoxical facilitation of the voltage-dependent calcium current following activation of GABAB receptors.- Stereospecific GABAB receptor antagonism.- A novel GABA response identified optically in the nucleus of the Tractus solitarius of the chick embryo.- GABAA and GABAB receptor ligands and their therapeutic application.- A novel benzodiazepine partial inverse agonist, S-8510, as a cognitive enhancer.- Spatial benzodiazepine receptor imaging in the human brain.- Does the GABAA receptor have a role to play in Angelman syndrome?.- Modulators of both GABAA receptor and cytosolic calcium level related to a novel treatment for epilepsy.- Muscimol induces state-dependent learning whereas baclofen impairs place learning in Morris water maze task in rats.- GABAB receptor antagonists: Potential therapeutic applications.- Expected therapeutic use of GABA agonists and antagonists for gut motility disorders.- GABAB antagonists block ?-butyrolactone-induced absence seizures and coordinated induction of transcription factors in mouse brain.- Pharmacological studies on generalized absence seizure regulation in genetic and drug-induced models.- Acknowledgements.- Keyword index.