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Gastroenterology and Hepatology: Bench to Bedside

Editat de Gourdas Choudhuri, Anil C Anand, P Piramanayagam
en Limba Engleză Hardback – 15 mai 2024
The book aims to be a handy compendium to the very voluminous texts of gastroenterology and hepatology existing in the knowledge market and provides the reader with an easy understanding of the bench knowledge (basic sciences) as they apply to bedside practice (clinical gastroenterology). With introduction and contributions from Prof Eamon Quigley, Former president of World Gastroenterology Organization and American College of Gastroenterology, the book covers the recent advances in the basic sciences that form an important pillar of the knowledge, thereby linking basic sciences such as anatomy, physiology, biochemistry, molecular medicine, etc. to clinical conditions, diseases and new therapeutic approaches in gastroenterology and hepatology. The book is written in a simple easy to read format, with a lot of diagrams and flowcharts, making it a handy guide. It also discusses in-depth about very common clinical conditions encountered in hospital settings such as ulcerative colitis, pseudomembranous colitis, colonic cancer, amebiasis, and various other syndromes and diseases. This book is a useful read for fellows and trainees in Gastroenterology and Hepatology, as well as gastroenterologists, hepatologists and physicians interested in digestive disorders.  
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Specificații

ISBN-13: 9789819992867
ISBN-10: 9819992869
Ilustrații: XXXIX, 505 p. 71 illus., 70 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 1.02 kg
Ediția:2024
Editura: Springer Nature Singapore
Colecția Springer
Locul publicării:Singapore, Singapore

Cuprins

Section 1. Esophagus



             A. Anatomy /Histology/Embryology
1. Lower Esophageal Sphincter    
2. Barret’s esophagus
3. Webs, rings, diverticulae in esophagus
4. Cross sectional anatomy of esophagus: Tumor staging
5. Esophagus in portal hypertension 
6. Tracheosophageal fistula
            B. Physiology
                   7. Acid clearance mechanism and defects in GERD
                   8. TLESR
                   9. Neurophysiological basis of esophageal peristalsis [normal manometry values
            C. Genetics
                 10. Genetic polymorphisms in GERD
                  11.Biomarkers in Barret’s esophagus
            D. Pathology
                  12. Pathogenesis of achalasia cardia 
                  13. Eosinophilic esophagitis: histopathology difference from reflux esophagitis
            E. Pharmacology
                  14. Drugs acting on the LES
                  



Section 2.  Stomach



A.  Anatomy and physiology
1. Cross sectional anatomy of stomach
2. Innervationof stomach- Types of vagotomy
3. Post GJ/gastrectomy anatomy
4. Parietal cell and the proton pump
5. Chief cell
6. Enterochromaffin cells in stomach
7. Fundic gland: histology
8. Pyloric glands: histology
9. Gastric pacemaker
10. Blood supply –Arterial, venous supply of stomach and GE junction
11. Lymphatic drainage of stomach
12. Gastric volvulus
13. Intestinal metaplasia and atrophic gastritis
14. Gastric bed/ Lesser sac/Foramen of Winslow
B. Physiology
                   15. Gastric mucosal defense and its breakdown in peptic ulcer
                   16. Gastric proton pump 
                   17. Neurohormonal control of gastric acid secretion
                   18. Gastric motility- Difference in fundus and body motility
                   19. Leptin
                   20. Motilin
                   21. Physiological basis of breath tests for H.Pylori
C. Genetics
                    22. H.Pylori virulence factors-cag, vac genes
                    23.Host genetic polymorphisms and outcome of H.Pylori infection
                    24. Host genetic polymorphisms and response to PPI
                    25.  c-kit mutation and response to therapy in GIST
          D.Pathology
                    26. Molecular pathogenesis of gastric cancer [Corea’s hypothesis] 
                    27.Pathogenesis of H.pylori associated gastric lymphoma
                    28. NSAID associated gastric mucosal injury
                    29. Autoimmune  gastritis
                    30. Granolomatosis  gastritis
          E. Microbiology
                    31. H.Pylori- structure, stains for H.pylori
          F. Pharmacology
                    32. PPI/ H2 blockers
                    33. Dopamine antagonists
                    34. Serotonin antagonists
                    



   Section 3. Small intestine



   A. Anatomy/ Histology/Embryology
1. Development of small intestine and malrotation
2. Meckel’s diverticulum
3. Neural plexuses: Meissner’s/Aeurbach’s plexus
4. Villous anatomy
5. Microvilli
6. Intraepithelial lymphocyte
7. Brunner’s gland 
8. M cells
9. Paneth cells
10. Zona occludens
11. Toll like receptors
12. Intestinal stem cells
              B.Physiology
                     13. MMC
                     14.Intestinal  Pacemaker
                     15.Intestinal Permeability
                     16.Small Bowel Permeability (SIP)
                     17. Mucosal Defence
                     18. Immunoglobulin A
                     19. Defensins
                     20. Enterokinase
                     21. Cholecystokinin
                     22. Secretin
23.Incretins
24.  Peptide YY- ileal brake
25. Brain gut axis
              C.Biochemistry 
                      26. Carbohydrate digestion 
                      27. Protein digestion
                      28. Lipid digestion
                      29. Vitamin B 12 absorption
                      30.Iron absorption and metabolism
                       31. Copper absorption
                       32. Vitamin D metabolism
                       33.Bile acid transport: Enterohepatic pathway
                       34. Cholestrol metabolism
  35.D-Xylose test
  36. Vande Krammer test
  37. Breath tests for malabsorption-physiological basis
  38. Breath tests for SIBO-physiological basis
           39. Intestinal adaptation 
               D. Pathogenesis
                         40. Protein losing enteropathy
                         41.Eosinophilic gastroenteritis
                        42.Celiac sprue
 43. Tropical sprue
                         44. Intestinal tuberculosis
                         45. SIBO
                         46.Short gut syndrome
                         47. Radiation enteritis
                         48.Indeterminate colitis
                         49. Pathogenesis of IBD
                E. Microbiology
50. Normal gut microbiota
51. Lifecycle of parasites
52. Bacterial toxins causing diarrhea
53. Opportunistic pathogens in HIV patients
54.ASCA and ANCA: Role in IBD
                 F. Pharmacology
55.Probiotics
56. ORS-New Vs old; super ORS
57.Zinc and its role in small intestinal diseases
58. Green banana diet
59. Vaccines for intestinal infection
60. Enteral nutrition-types and indications
61. Immunonutrition
62. 10.5-ASA preparation and small intestinal release
63. TPMT assay and azathioprine metabolism
64. Biologicals in I BD
65. Methotrexate  and folic acid
                G. Genetics
                           66. CARD/ NOD genes
                           67. Genetics in IBD/IBD genes -Indian scenario 
                           68. Lactase genes



Section 4. Large intestine



                    A. Anatomy/ Histology/Embryology
1. Anal sphincters
 2. Dentate line 
 3. Rectal folds (Valves of Houston) 
 4. SRUS-Histopathology
 5. Adenomatous polyps- Types and significance
 6. Juvenile and hamartomatous polyps
                     B. Physiology
7. RAIR
 8. Fluid handling by intestine
 9. Colonic motility
10. Defecation-mechanism
11. Intestinal fistulas
                     C. Biochemistry
12. Short chain fatty acids
13. Fecal occult blood test- Types, limitations
                     D. Pathogenesis
14.  Ulcerative colitis
15. Pseudomembranous colitis
16.  Molecular pathogenesis of colonic cancer
17. Amebiasis
18. Microscopic colitis
 19. Newer concepts in pathogenesis of IBS
20. Montreal classification of IBD
21. Pathogenesis of pseudo-obstruction



Section 5 . Liver



                      A. Anatomy/Histology/ Embryology
1. Hepatocyte
2. Cholangiocyte
3. Ito cell
4. Stellate cell
5. Hepatic stem cell
6. Kupffer cells
7. Hepatitis B- structure and replication
8. Hepatitis C –structure and replication
9. Hepatitis E- structure
10. Hepatic sinusoid
11. Venous drainage of liver- importance in Budd Chiari syndrome
12. Ligaments of liver, surface anatomy of liver
13. Segments of liver
 14 .HBV mutants
15. IL-28B polymorphism and HCV
                        B.Physiology
                                     16. Bilirubin metabolism and congenital disorders
                                     17. Bile salt metabolism-enterohepatic shunts, congenital disorders
                                     18. Liver as an immunological organ
                                     19. Ammonia handling in liver, kidney, brain, muscles
                                     20. Ethanol metabolism
                                     21. Aminoacids- Branched chain : relevance in liver disease
                                     22. Urea cycle and congenital defects
                                     23. Eneterohepatic Circulation
                         C. Pathology
                                     24. Necroinflammatory and fibrosis scores
                                     25. Pathogenesis of alcoholic liver disease
                                     26. NAFLD-Pathogenesis
                                     27. Wilson’s disease
                                     28. Hemochromatosis
                                    29. Glycogen storage disorders
                                     30. HCC-molecular pathway
                                     31. Hepatic fibrosis- pro and antifibrotic mechanisms
                                     32. Hepatic encephalopathy- pathogenesis
                                     33. HRS- pathophysiology
                                     34. Ascites in liver disease – pathogenic mechanism
                                     35. NCPF: pathogenesis
                                     36. EHPVO: pathogenic mechanisms
                                     37. Pathogenesis of portal hypertension in cirrhosis – role of structural and        functional reasons for portal hypertension 
                                     38. Pathogenesis of hepato-pulmonary syndrome 
                                     39. Pathogenesis of ALF   
                                     40. Endocrine complications in cirrhosis      
                        D. Microbiology
                                     
                                     41. Genotyping methods
                                     42. ELISA 
                                     43. HBV life cycle
                                    44. HCV replicon
                                    45. Malarial, enteric, dengue  hepatopathy
                                    46. Mechanisms of HBV and HCV related HCC
                                    47.HCV and steatosis
                                    
                        E. Pharmacology
                                    48. Interferons
                                    49 Ribavirin
                                    50. Eltrombopag
                                    51. Sorafenib
                                    52. Nucleoside analogues/nucleotide in HBV therapy
                                    53. L-Ornithine L- Aspartate
                                    54. Lactulose and other ammonia lowering agents
                                    55. Somatostatin analogues
                                    56. Role of viral kinetics in HCV treatment
                                    57. Role of HBsAg titre in HBV treatment
                                    58. Side effects of oral antiviral therapy and its pathogenesis

            

Section 6. Bile duct, Gall bladder and Pancreas



                   A. Anatomy/ histology/ embryology
1. Pancreas development- Pancreas divisum, Annular pancreas, Ducts of Morgagani, Santorini
2. Choledochal cyst- Todani classification, types
3. Lesser sac anatomy-pancreatic pseudocyst
4. Sphincter of Oddi 
5. Pancreatic stellate cells
6. Pancreatic stem cells 
7. Pancreas- endocrine functions- Pancreatic neuroendocrine tumors
                     B. Physiology
                                     8. Bile production- bile acid dependent and -independent mechanisms
                                     9. Gallbladder bile Vs duodenal bile- changes incompositon
                                   10. Neurohormonal control of pancreatic secretion
                                   11. Neurohormonal control of biliary secretion
                                   12. Normal pressures in pancreatic and bile ducts
                                   13. Pancreatic enzymes- functions and feedback regulation
                      C. Pathology
                                   14. Microlithiasis
                                   15. Gallstone formation- supersaturation, nucleation, gallbladder dysmotility
                                   16. Gallstone- types and composition
                                   17. Pathophysiology of alcoholic chronic pancreatitis
                                   18. Pathophysiology of acute pancreatitis
                                   19. Pancreatic malignancy-molecular mechanism
                                   20. Cystic neoplasms of pancreas-Difference from pseudocyst
                                   21. Autoimmune pancreatitis
                                   22. Gallbladder carcinoma- etiopathogenesis
                                   23. PSC
                                   24. PBC
                                   25. Pain in chronic pancreatitis- pathophysiology
                      D. Pharmacology
                                   26.Octreotide
                                   27. Pancreatic enzyme supplements
                                   28. Ursodeoxycholic acid
                                   29. Statins
                                   

                E. Genetics
                                   31. Genes in chronic pancreatitis with relevant Indian data
                                   32. Genetic polymorphisms in gallstone disease



          


  Section 7.  Miscellaneous

       
                     1. SiRNA
                     2. Genetics of celiac disease
                     3. Cannabanoid receptors
                     4. Cadherins
                     5 . Carcinoids in GI / Carcinoid syndrome
                     6.  CMV disease in GI and Liver
                     7. Role of Integrins: development of biologics like natalizumab
                     8. Wnt: GI Stem cells  B-catemin
                     9.  Hedgehog: role in pancreas
                    10. EGFR/ receptor tyrosine kinases/  K Ras
                    11. IFN signalling: antiviral immunity
                    12. Overview  of innate immunity
                    13. T cell subsets:  Th1, Th2, Th17
                    14. B cells / Eosinophils
                    15. TGF B pathway
                    16. G Coupled protein receptors
                    17. Small  GTPases : Rho/ Rac/ CDC 42
                     18. Angiogenesis
                                19. GWAS
                                20.Transcription factors
                                21. Oncogenes
                               22.Tumor suppressor genes
                                23.Telomerase
                                24.  Liver nuclear receptors
                                25. Role of Vit D in GI diseases
                                26. Apoptosis
                                27. Gene therapy in Gastroenterology
                                28. Stem cells in Gastroenterology






Notă biografică

Dr.Gourdas Choudhuri, MD (Medicine), DM(Gastroenterology), FACG, FAMS, FICP, FRCP, Chairman and Head, Department of Gastroenterology and Hepato-biliary Sciences, Fortis Memorial Research Institute, Gurgaon, Haryana, India
Dr. A. C. Anand MD (Medicine), DM (Gastroenterology), FICP, FSGEI, FRCP(London), FRCP (Edinburg), FACP, FACG, FAMS, Professor and Head, Department of Gastroenterology & Hepatology
Kalinga Institute of Medical Sciences, Bhubaneshwar, India
Dr Piramanayagam P,  MD (Medicine), DM Gastroenterolgy), Consultant, Department of Gastroenterology, Apollo Hospitals 21, Greams Lane, Off Greams Road Chennai, India

Textul de pe ultima copertă

The book aims to be a handy compendium to the very voluminous texts of gastroenterology and hepatology existing in the knowledge market and provides the reader with an easy understanding of the bench knowledge (basic sciences) as they apply to bedside practice (clinical gastroenterology). With introduction and contributions from Prof Eamon Quigley, Former president of World Gastroenterology Organization and American College of Gastroenterology, the book covers the recent advances in the basic sciences that form an important pillar of the knowledge, thereby linking basic sciences such as anatomy, physiology, biochemistry, molecular medicine, etc. to clinical conditions, diseases and new therapeutic approaches in gastroenterology and hepatology. The book is written in a simple easy to read format, with a lot of diagrams and flowcharts, making it a handy guide. It also discusses in-depth about very common clinical conditions encountered in hospital settings such as ulcerative colitis, pseudomembranous colitis, colonic cancer, amebiasis, and various other syndromes and diseases. This book is a useful read for fellows and trainees in Gastroenterology and Hepatology, as well as gastroenterologists, hepatologists and physicians interested in digestive disorders.  

Caracteristici

Connects the knowledge of basic sciences to clinical conditions and diseases in gastroenterology and hepatology. Serves as a -easy-to-read and understand handbook for fellows and young clinicians Discusses about the various diseases commonly encountered in hospital settings