Gene Therapy and Cancer Research Focus de Rebecca N. Campbell

Gene Therapy and Cancer Research Focus

Rebecca N. Campbell

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.

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Cuprins

Preface; Expert commentary; Sodium iodide symporter -- a promising new technology for cancer treatment; Short communication; Vector-producing mesenchymal stem cells for cancer gene therapy; Research and review studies; Preclinical and clinical development of transcriptionally controlled oncolytic adenoviruses; Nuclear transportation factor kappa B; Artificial genetic circuits and cancer gene therapy; Genetic modification of t lymphocytes for cancer therapy; The immune response to tumor-associated antigens in hematological malignancies -- its relevance for vaccine development; HDAC inhibitors upregulate the coxsackie/adenovirus receptor (CAR); The pivotal role of the oncofetal H19 rna in human cancer, a new hope; Gene delivery and gene silencing in experimental liver cancer models; Genetic engineering for cancer immunotherapy; The new era for bacterial targeted tumour therapy; Index.