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Genetic Toxicology and Cancer Risk Assessment de Wai Nang Choy

Genetic Toxicology and Cancer Risk Assessment

Autor Wai Nang Choy
en Limba Engleză Hardback – 31 aug 2001
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!

This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.

Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!

Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment
  • reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis
  • calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens
  • reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models
  • discusses the threshold concept of carcinogenesis
  • demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens
  • considers structural activity relationship (SAR) analysis of chemical carcinogenicity
  • describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays
  • illustrates the use of genetic biomarkers for dosimetry analysis
  • and more!
    Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
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    Specificații

    ISBN-13: 9780824702946
    ISBN-10: 0824702948
    Pagini: 404
    Dimensiuni: 152 x 229 x 23 mm
    Greutate: 0.61 kg
    Ediția:1
    Editura: CRC Press
    Colecția CRC Press
    Locul publicării:Boca Raton, United States

    Public țintă

    Professional

    Recenzii

    "
    …engaging and informative….
    …a useful contribution to the field of genetic toxicology.
    "-Doody

    "…well-detailed….
    …a great reference material.
    "-Australian Journal of Medical Science

    "…offers the reader an authoritative, practical insight.
    "-Cancer Forum

    Cuprins

    Human Cancer Genetics Jason W. Barlow and David Malkin Genetic Toxicity Tests for Predicting Carcinogenicity Errol Zeiger Genotoxic and Nongenotoxic Mechanisms of Carcinogenesis Wai Nang Choy Structure-Activity Relationship (SAR) and its Roles in Cancer Risk Assessment David Y. Lai and Yin-tak Woo Regulatory Genetic Toxicology Tests Wai Nang Choy Complementary Genetic Toxicology Assays B. Bhaskar Gollapudi The Mouse Lymphoma Assay (MLA) Using the Microwell Method Masamitsu Honma and Toshio Sofuni The In Vitro Micronucleus Assay Marilyn J. Aardema and Micheline Kirsch-Volders ICH Guidelines on Genotoxicity and Carcinogenicity: Scientific Background and Regulatory Practice Lutz Müller, Peter Kasper, and Leonard Schechtman New OECD Genetic Toxicology Guidelines and Interpretation of Results Michael C. Cimino Dose-Response Relationships in Chemical Carcinogenesis and Cancer Risk Assessment Werner K. Lutz Molecular Epidemiology and Biomarkers Jia-Sheng Wang, Jonathan M. Links, John Groopman Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens Anna M. Fan and Robert A. Howd Risk Assessment of Genotoxic Carcinogens Lauren Zeise Biologically Based Cancer Risk Assessment Models Suresh H. Moolgavkar

    Descriere

    Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!

    This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.

    Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!

    Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment
  • reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis
  • calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens
  • reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models
  • discusses the threshold concept of carcinogenesis
  • demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens
  • considers structural activity relationship (SAR) analysis of chemical carcinogenicity
  • describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays
  • illustrates the use of genetic biomarkers for dosimetry analysis
  • and more!
    Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
    •