Tuberculosis (TB) still remains the largest cause of death in the world from a single infectious disease & also the most common opportunistic infection in AIDS patients globally. Genitourinary Tuberculosis (GUTB) accounts for about one-third cases of nonpulmonary TB. Resurgence of TB has occurred in recent years due to an expanding pool of immune-suppressed patients, notably HIV-infected individuals, large immigrant populations from developing nations & the development of multidrug-resistant TB. Despite contributing to a lot of morbidity like recurrent urinary tract infections, hematuria, hydronephrosis due to ureteral strictures, infertility etc., there is scarcely any literature regarding genitourinary TB-its manifestation, diagnosis and treatment, making its detection & management very challenging. This analysis is an in-depth review of a sizeable number of cases of Genitourinary TB-their clinical presentation, diagnostic modalities, medical & surgical management & will be of immense use to medical students, medical & surgical residents, community health workers, surgeons, urologists, practitioners and anyone else involved with the treatment of TB and HIV.