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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine

Autor Henry H. Heng
en Limba Engleză Paperback – 28 mai 2019
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.


  • Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine
  • Gathers the most pressing questions in genomic and cytogenomic research
  • Offers alternative explanations to timely puzzles in the field
  • Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more
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Specificații

ISBN-13: 9780128136355
ISBN-10: 0128136359
Pagini: 556
Dimensiuni: 152 x 229 x 45 mm
Greutate: 0.84 kg
Editura: ELSEVIER SCIENCE

Public țintă

Active researchers, basic and translational scientists, clinicians, historians and philosophers of science, and students in the areas of human genetics, genomics, molecular biology, evolutionary biology, and cancer research

Cuprins

1. From Mendelian Genetics to 4D-Genomics2. Genes and Genomes Represent Different Biological Entities 3. Genome Chaos and Macro-cellular Evolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer4. Chromosomal Coding and Fuzzy Inheritance5. Why sex? Genome Re-interpretation Dethrones the Queen6. Breaking the Genome Constraint: The Mechanism of Macro-evolution7. The Genome Theory: A New Framework8. The Rationale and Challenges for Precision Medicine