Izuchenie gipertonicheskoy entsefalopatii yavlyaetsya aktual'noy problemoy v nevrologii, dannaya patologiya privodit k vyrazhennym narusheniyam v dvigatel'noy, kognitivnoy i emotsional'noy sferakh, dezadaptatsii bol'nykh i ikh ranney invalidizatsii. Eto opredelyaet ne tol'ko meditsinskuyu, no i sotsial'nuyu znachimost' problemy. Osobyy interes vyzyvaet izuchenie gipertonicheskoy entsefalopatii v period menopauzy, tak kak imenno v etot period u zhenshchin proiskhodit razvitie ili usugublenie arterial'noy gipertenzii - osnovnogo faktora riska razvitiya gipertonicheskoy entsefalopatii. Dlya izucheniya kliniko-nevrologicheskikh i patogeneticheskikh osobennostey techeniya gipertonicheskoy entsefalopatii u zhenshchin menopauzal'nogo perioda v dannoy monografii primenen mnogourovnevyy sistemnyy podkhod v vide tserebro-kardial'nogo, vegetativno-endokrinnogo, laboratorno-immunologicheskogo i psikhosomaticheskogo issledovaniy, a takzhe rasshirena stratifikatsiya faktorov riska razvitiya gipertonicheskoy entsefalopatii u zhenshchin na fone perimenopauzy v zavisimosti ot vyrazhennosti klimaktericheskogo sindroma. Vpervye opredeleny neyroimmunologicheskie kriterii, svidetel'stvuyushchie o progredientnom techenii gipertonicheskoy entsefalopatii u zhenshchin.