The COVID-19 pandemic has laid bare the world's vulnerabilities to health and economic ruin from disease outbreaks. But the pandemic merely reveals fundamental weaknesses and contradictions in global health. What are the roots of discontents in global health? How do geo-politics, power dynamics, knowledge gaps, racism, and corruption affect global health? Is foreign aid for health due for a radical overhaul? This book is an incisive guide to the practice of global health in real life. Global health policy is at a crossroads. It is on trial at the interface between the Global North and the Global South. There has been remarkable progress in health outcomes over the past century. Yet, countries face a complex landscape of lofty ambitions in the form of political commitments to Universal Health Coverage, Human Capital, and Global Health Security. These ambitions are tempered by multiple constraints. Investors in global health must navigate a minefield of uneven progress, great expectations, and denials of scientific evidence by entrenched interests. That terrain is further complicated by the hegemonic suppression of innovation that threatens the status quo and by self-perpetuating cycles of dependency of the Global South on the Global North. This book is an unflinching scrutiny of concepts and cases by a veteran of global health policy and practice. It holds a mirror to the world and lays out pathways to a better future. The book is a must-have GPS for policy makers and practitioners as they navigate the maze of global health.