A resistant bacterial strain is plaguing the city of Detroit and is quickly spreading to other parts of the country. Dr. Eunice Sabara, an openly lesbian woman who is also a renowned infectious disease specialist, is working around the clock to find a cure when she's brutally murdered in her home office. Dr. Sabara's assailants also destroy her computer's hard drive, which contains the cure for the resistant bacterial strain, effectively destroying with it the hopes of thousands of people who have already contracted the disease. Detective Rein Connery is assigned the task of tracking down Dr. Sabara's killers. While getting the job done, Rein befriends a battle-weary yet far from defeated Joby Rowe and a whole host of her allies, a group of self-described "transgender warriors" (a term coined by Leslie Feinberg's book of the same name) who aren't afraid to live their lives as they see fit. Joining Joby in this colorful, if not grimly realistic, slice of Americana are Mattie Duncan, a woman whose gender-identity doesn't quite match her sex; Raymond Lazaro Ferra, a cross-dressing, heterosexual male; Candy Brown, a former man who has undergone sexual reassignment and couldn't be happier as a woman; and teenager Yvonne Rasmussen, a heterosexual female who believes that people should be allowed the freedom to dress, act, and express themselves in ways that make them happy.