GPCRs as Therapeutic Targets, Two Volume Set

Chapter 1 - An overview of G protein coupled receptors and their signaling partners Chapter 2 - Recent advances in orphan GPCRs research and therapeutic potential Chapter 3 - The Evolution of Our Understanding of GPCRs Chapter 4 - Approaching GPCR dimers and higher order oligomers using biophysical, biochemical and proteomic methods Chapter 5 - Arrestin and G protein interactions with GPCRs: a structural perspective Chapter 6 - GPCRs at endosomes: sorting, signaling, and recycling Chapter 7 - Post-translational Control of GPCR Signaling Chapter 8 - GPCR Signaling from Intracellular Membranes Chapter 9 - Ten years of GPCR structures Chapter 10 - Activation of class B GPCR by peptide ligands: general structural aspects Chapter 11 - Dynamical basis of GPCR-G-protein coupling selectivity and promiscuity Chapter 12 - Virtual Screening and Bioactivity Modeling for G Protein-Coupled Receptors Chapter 13 - Importance of structure and dynamics in the rational drug design of G protein-coupled receptor (GPCR) modulators Chapter 14 - Signaling, Physiology and Targeting of GPCR-Regulated Phospholipase C Enzymes Chapter 15 - G Protein-coupled Receptors in Metabolic Disease Chapter 16 - Endothelin Receptors in cerebrovascular diseases Chapter 17 - The calcium-sensing receptor (CaSR) in disease Chapter 18 - G protein-coupled receptors and their mutations in cancer - a focus on adenosine receptors Chapter 19 - Dopamine Receptors: Neurotherapeutic Targets for Substance Use Disorders Chapter 20 - PTHR1 in bone Chapter 21 - Activators of G-protein Signaling in the normal and diseased kidney Chapter 22 - Screening and characterization of GPCR-ligand interactions with mass spectrometry-based technologies Chapter 23 - Bioluminescence resonance energy transfer (BRET) technologies to study GPCRs Chapter 24 - The Application of 19F NMR to Studies of Protein Function and Drug Screening Chapter 25 - Chapter X: Optical Approaches for Dissecting GPCR Signaling Chapter 26 - GPCR Signaling in Nanodomains: Lessons from Single-Molecule Microscopy