The semi-arid grasslands in the Mexico-United States border region are relatively intact and provide one of the best opportunities in North America to preserve and nurture an extensive series of grassland ecosystems. The conference was organized to increase appreciation for the importance of the remaining semi-arid grasslands and to create a platform for expanding the integration of natural and social sciences among individuals and organizations. The conference was attended by ranchers, environmentalists, academics, and agency personnel from both nations. Main topics include grassland ecology and biodiversity, management and conservation, and sustainable borderland ranching. Endangered species management, especially of black-tailed prairie dogs (Cynomys ludovicianus), was an important topic. Oral presentations were in English or Spanish, with simultaneous translations, and the papers have been printed in both languages. The conference revealed the ties between ecological processes and environmental conditions in the Borderland grasslands and the cultural and economic priorities of the human communities who depend on them. This recognition should enable interested people and groups to work together to achieve satisfactory solutions to the challenges of the future.