The objectives of these guidelines are to provide a summary of the key evidence and practice recommendations on the diagnosis and treatment of the main skin and oral conditions in HIV-infected adults and children. These guidelines describe common HIV-related dermatologic and oral conditions in resource limited settings and their differential diagnoses, and include treatment strategies that are likely to be available locally. Details are provided about an algorithmic tool being developed by a multi-agency group led by WHO to aid in diagnosis based on expert opinion by clinicians working in HIV dermatology.