Guillain-Barré Syndrome: Clinical Medicine and the Nervous System

1 History and Definition.- Landry’s Acute Ascending Paralysis.- Acute Febrile Polyneuritis.- Acute Infective Polyneuritis.- A Syndrome of Radiculoneuritis with Albumino-cytological Dissociation.- Guillain-Barré Syndrome or Landry’s Ascending Paralysis.- Chronic Idiopathic Demyelinating Polyradiculoneuropathy.- Guillain-Barré Syndrome in History and the News.- Summary.- References.- 2 Immunobiology of the Peripheral Nervous System.- Wallerian Degeneration Versus Primary Demyelination.- Myelin.- Blood-Nerve Barrier.- Antigen Presentation in the Peripheral Nervous System.- Final Common Pathway of Immunologically Mediated Demyelination.- Antibody-Mediated Demyelination.- Antibody-Dependent Cell-Mediated Demyelination.- Cell-Mediated Cytotoxicity Causing Demyelination.- Delayed Hypersensitivity to Myelin Antigens Causing Demyelination.- Bystander Demyelination.- Summary.- References.- 3 Experimental Allergic Neuritis.- Experimental Allergic Encephalomyelitis.- Pathology of EAN.- Neurological Signs of EAN.- Experimental Autonomic Neuropathy.- Chronic Relapsing Experimental Allergic Neuritis.- Neurophysiology.- Cerebrospinal Fluid.- Identification of the Antigen Responsible for EAN.- Genetic Factors.- Antibody Production in EAN.- Cell-Mediated Immunity in EAN.- Galactocerebroside Neuritis.- Treatment of EAN.- Summary.- References.- 4 Pathology of Guillain-Barré Syndrome.- Autopsy Observations of Guillain-Barré Syndrome.- Biopsy Studies in Guillain-Barré Syndrome.- Immunohistochemical Studies of Nerves in GBS.- Remyelination.- Summary.- References.- 5 Epidemiology.- Swine Influenza Vaccine Epidemic.- Post-Rabies Vaccine Neuritis.- Viral Infections as Antecedent Events.- Mycoplasma, Bacterial and Other Infections as Antecedent Events.- Other Possible Precipitants ofGBS.- Summary.- References.- 6 Clinical Features of Guillain-Barré Syndrome.- Presentation.- Clinical Course.- Differential Diagnosis.- Miller Fisher Syndrome.- Autonomic Dysfunction.- Papilloedema.- Other Complications.- Summary.- References.- 7 Clinical Neurophysiology.- Frequency of Abnormalities of Motor Nerve Conduction.- Time Course of Nerve Conduction Abnormalities.- Sensory Nerve Conduction.- Axonal Degeneration in GBS.- Myokymia in GBS.- Evoked Potentials.- Electrophysiological Evidence and Prediction of Prognosis.- Mechanisms.- Summary.- References.- 8 Treatment of Guillain-Barré Syndrome.- Prognosis.- General Care.- Steroids.- Plasma Exchange.- Intravenous Immunoglobulin.- Immunosuppressive Drugs.- Rehabilitation.- Summary.- References.- 9 Immunology of Guillain-Barré Syndrome.- Cerebrospinal Fluid.- Diseases Associated with Guillain-Barré Syndrome.- HLA Associations.- Immunoglobulins, Complement and Immune Complexes.- Complexes.- Antibodies.- Cellular Immunity.- Summary.- References.- 10 Chronic Idiopathic Demyelinating Polyradiculoneuropathy.- Diagnostic Criteria.- Preceding Events.- Clinical Features.- Differential Diagnosis.- Evidence for CNS Involvement in CIDP.- Neurophysiology.- Cerebrospinal Fluid.- Pathology.- Immunology.- Treatment.- Summary.- References.- 11 Animal Models of Guillain-Barré Syndrome.- Marek’s Disease.- Coonhound Paralysis.- Animal Idiopathic Polyradiculoneuropathy.- Cauda Equina Neuritis of the Horse.- Summary.- References.- 12 Other Inflammatory or Demyelinating Neuropathies.- Vasculitic Neuropathy.- Sarcoid Neuropathy.- Plasma Cell Dyscrasias and Neuropathy.- Leprosy.- Human Immunodeficiency Virus Infection and Neuropathy.- Summary.- References.- Appendix. Guillain-Barré Syndrome: A Short Guide for the Patient, Relativeand Friend.