GenNnet, a genetic engineering firm, accidentally stumbles upon a way to alter DNA that results in changes in personality and human behavior. The alteration creates human collectives where individuals, while normal and content in every way, are motivated to work for the benefit of society. When Phil Graham, GenNnet's head of research, discovers the amazing results, he creates a plan to expose the entire planet in the name of achieving world peace. His plan evolves into a bloodless takeover of the United States government and countries in the G20. Things get complicated when an exposed person turns up missing and prompts an investigation by the local police that later escalates to the FBI. Coincident with the GenNnet discovery, two young scientists combine their respective disciplines to move the evolutionary clock thousands of years forward. Their research goes beyond man's next step in human evolution known as H2. What will man be like 100,000 years into the future? The answers may be surprising. Tom Randall, a renowned scientist in the field of biochemistry and genetic research, is the main character of the story. He becomes deeply involved in both GenNnet's discovery and the experiments conducted by his two sons. The plot thickens when FBI Agent Miles Dowling suspects the use of Nanotechnology in the GenNnet formula and he seeks the help of Tom's son in his investigation. H3 utilizes an interesting blend of fact and fiction to highlight how ultimate control can lead to ultimate corruption.