Hairy-cell Leukaemia
Autor John Burthem, John C. Cawleyen Limba Engleză Paperback – 6 oct 2011
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Specificații
ISBN-13: 9781447112563
ISBN-10: 1447112563
Pagini: 128
Ilustrații: IX, 111 p.
Dimensiuni: 155 x 235 x 7 mm
Greutate: 0.19 kg
Ediția:Softcover reprint of the original 1st ed. 1996
Editura: SPRINGER LONDON
Colecția Springer
Locul publicării:London, United Kingdom
ISBN-10: 1447112563
Pagini: 128
Ilustrații: IX, 111 p.
Dimensiuni: 155 x 235 x 7 mm
Greutate: 0.19 kg
Ediția:Softcover reprint of the original 1st ed. 1996
Editura: SPRINGER LONDON
Colecția Springer
Locul publicării:London, United Kingdom
Public țintă
ResearchCuprins
1 Introduction and Historical Aspects.- 2 Clinical Aspects.- 2.1 Clinical features.- 2.2 Laboratory features.- 2.3 Prognosis: staging systems.- 3 Pathology.- 3.1 Bone marrow.- 3.2 Spleen.- 3.3 Liver.- 3.4 Lymph nodes.- 3.5 Other blood cells.- 3.6 Viruses and HCL.- 4 Diagnosis and Hairy-like Disorders.- 4.1 The diagnosis of typical HCL.- 4.2 Diagnosis when few abnormal cells are present.- 4.3 Diagnosis of HCL in the presence of atypical clinical or pathological features.- 4.4 Variant forms of HCL and closely related conditions.- 4.5 Atypical and rare presentations.- 5 Treatment: Mechanisms.- 5.1 Mechanism of action of splenectomy.- 5.2 The mechanism of action of ?IFN.- 5.3 Mechanism of action of the purine analogue drugs.- 6 Treatment: Practical Considerations.- 6.1 When should treatment be commenced?.- 6.2 Splenectomy.- 6.3 Interferon.- 6.4 Purine analogue drugs: DCF, CDA and fludarabine.- 6.5 The use of colony-stimulating factors in HCL.- 6.6 Overview of therapeutic options.- 6.7 Treatment after failure of primary treatment option.- 6.8 Other treatment options.- 7 The Hairy Cell.- 7.1 Cytology.- 7.2 Cytochemistry.- 7.3 Cytogenetics.- 7.4 Ultrastructure.- 7.5 Nature of the malignant cell.- 7.6 Membrane, cytoskeletal organisation and signalling.- 7.7 Response to cytokines.- 7.8 Adhesion and tissue localisation.- 7.9 Cell survival and cell death.- Appendices.- Appendix A: Tartrate-resistant acid phosphatase (TRAP).- Appendix B: CD-antigen expression by HCs.- References.
Recenzii
"This excellent little book brings together a lot of the knowledge obtained in the last 40 years and I enjoyed reading it...I have no hesitation in recommending this book. It is well written, authoritative and practical. All haematologists should have access to it." Cancer Forum